Mutagenicity of Azathioprine1
نویسنده
چکیده
Azathiopnine was without significant mutagenic potential (Table 1, Experiment 1) when exposure of the bacteria to the drug was carried out under the standard procedure developed by Ames et a!. (1, 3). However, when the initial exposure of the bacteria to the test agent was allowed to occur under anaerobic conditions, a mutagenic effect was cleanly demonstrable (Table 1, Experiment 1). This effect was dependent on azathiopnine concentration (Table 1, Ex periment 2). It was demonstrated that the initial period of anaerobic incubation had no significant effect on the mutagenic activ ity of a number of agents that display activity under aerobic conditions as well (Table 1, Experiment 3).
منابع مشابه
Mutagenicity Effect of Antimigrin Herbal Medicine
ABSTRACT The increasing use of medical herbs and their products and the proof of mutagenicity and oncogenicity of some of their components justify more researches about these effects of herb products. The objective of the present study is to explore the cytogenetic toxicity of a product currently available in Iranian drug market called Antimigrin. One of the methods used for the study of mutag...
متن کاملAmes Mutagenicity Assessment of Flavored Water Pipe Tobacco Products :A Cross Sectional Study in Tehran
Waterpipe smoking has become a global youth trend especially in the Middle East countries and Iran . The aim of this study was to determine the mutagenic effects of three most popular flavored tobaccos by four different salmonella typhimurium strains and compare the possible mutagenic effects of the test samples. Ames mutagenicity assessment was conducted according to the OECD guideline using T...
متن کاملEvaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملEvaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کامل